Letrozole Tablets

Letrozole is a nonsteroidal oral aromatase inhibitor. It is used in postmenopausal women for the adjuvant treatment of early breast cancer, for extended adjuvant therapy after 5 years of tamoxifen, and for the treatment of advanced breast cancer. It is also used off-label for the treatment of infertility, idiopathic short stature in boys, and delayed puberty in boys. Unlike aminoglutethimide, an early aromatase inhibitor, letrozole does not inhibit adrenal steroid synthesis; therefore, glucocorticoid or mineralocorticoid replacement therapy is not necessary. The use of letrozole is contraindicated in pregnancy. Decreases in bone mineral density and increases in total cholesterol may occur; monitoring is recommended.