Ketamine Nasal Spray
Ketamine, C13H16ClNO, is a synthetic racemic mixture of R-ketamine and S-ketamine (esketamine). Ketamine is a derivative of phencyclidine (PCP) and is considered a DEA Schedule III controlled substance
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Description
Ketamine Nasal Spray
Ketamine was first FDA-approved in under the brand name Ketalar and is commonly used as an anesthetic for both pediatric and adult surgical procedures.
Ketamine is not FDA-approved for depression, but esketamine (S-ketamine), the S(+) enantiomer of ketamine, is. In 2019, the FDA approved Spravato (esketamine) nasal spray, in conjunction with oral antidepressant medication, to treat adults with treatment-resistant depression and depressive symptoms in adults with major depressive disorder (MDD) with suicidal thoughts or actions. Esketamine nasal spray is only available with a prescription and through a restricted Risk Evaluation and Mitigation Strategy program that is strictly implemented and monitored by a licensed healthcare provider. Esketamine nasal spray is not FDA-approved as an anesthetic agent.
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